Table 1.

The effect of increasing concentrations of 5-CT on diastolic blood pressure (DBP) and meningeal blood flow (MBF) in anesthetized rats pretreated either with vehicle (physiological saline; 1 ml/kg, i.v.), GR-127935 (GR; 1 mg/kg, i.v.), SB-269970 (SB; 1 mg/kg, i.v.), or GR-127935 + SB-269970 (GR + SB; 1 mg/kg, i.v. each). 5-CT was administered as a topical solution (100 μl) directly on the exposed dura mater encephali. Data are presented as the percent change from baseline values (mean ± S.E.M.).

		5-CT concentration (μM)
Treatment	Parameter	0.01	0.1	1	10	100	1000
Vehicle (n=8)	DBP	−0.2±1	2±1	−1±2	−2±2	−27±7 a	−51±7 a
	MBF	−2±1	1±2	−1±1	−0.1±4	−17±7 a	−20±9 a
GR (n=7)	DBP	−0.4±1	−0.1±1	1±1	−2±1	−15±4a b	−35±3a b
	MBF	8±3	6±2 a	5±1a	7±3a	−8±5	3±12
SB (n=6)	DBP	−0.4±2	−2±1	1±1	−2±1	−3±1b c	−15±4a b c
	MBF	−1±2	−1±1	−0.4±1	−2±3	−0.3±2 b	−1±6 b
GR + SB (n=6)	DBP	−1±1	−1±0.3	−1±1	−1±1	3±2b c	−4±1a b c d
	MBF	1±1	−1±1	−3±2	3±3	2±2 b	1±2 b

^aP < 0.05 vs baseline;

^bP < 0.05 vs vehicle;

^cP < 0.05 vs GR;

^dP < 0.05 vs SB