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"Hand-off" mechanism model for ubiquitinated cargos. Ub receptors (A and C), recognizing the hydrophobic patch centred on Ile44 (depicted in black), are intercalated with others (B), recognizing different region of Ub (depicted in white). Rabex-5, through ZnF_A20 domain, recognizes the polar patch centred on Asp58 and represents an example of Ub receptors B. Endosome is depicted as prototype of trafficking organelles.
