Table 1.

Partial list of genes that show tissue-specific changes

Probe set	Gene symbol (name)	Fold change
Pancreas
113815_at	Ctrc* (chymotrypsin C)	23.2
102755_at	Itlna* (intelectin a)	13.7
97658_f_at	Ins1* (insulin I)	1.7
100407_at	Gal* (galanin)	−1.8
99488_at	Iapp* (islet amyloid polypeptide)	−1.8
165472_i_at	Gcg* (glucagon)	−1.9
137506_at	Rhoq (Ras homolog gene family, member Q)	−2.8
103367_at	Galgt1* (β-1,4-N-acetyl-galactosaminyl transferase 1)	−30.6
Submandibular gland
98480_s_at	Ren1, Ren2 (renin 1, renin 2)	691.0
101636_at	Spt2 (salivary protein 2)	128.5
104496_i_at	Klk8 (kallikrein 8)	5.7
98391_at	Klk11 (kallikrein 11)	3.0
104497_f_at	Klk8 (kallikrein 8)	2.5
168876_f_at	Klk21 (kallikrein 21)	1.9
100719_f_at	Klk16 (kallikrein 16)	1.9
162305_f_at	Klk1, Klk9 (kallikrein 9, kallikrein 1)	1.8
102693_f_at	Klk26 (kallikrein 26)	1.8
92606_at	Uox (urate oxidase)	−17.0
Lacrimal gland
92837_f_at	Mug1* (murinoglobulin 1)	5.4
92601_at	Pnliprp1 (pancreatic lipase-related protein 1)	3.0
111006_at	Plcb1 (phospholipase C, β1)	3.0
167894_f_at	Lgals8 (lectin, galactose-binding, soluble 8)	2.2
96054_f_at	Acp1 (acid phosphatase 1, soluble)	2.1
112766_at	Lman1* (lectin, mannose-binding, 1)	2.1
99669_at	Lgals1 (lectin, galactose-binding, soluble 1)	−1.7
166259_f_at	Ctsc* (cathepsin C)	−21.8

Genes are grouped according to their tissue origin (pancreas, submandibular gland, and lacrimal gland). Gene symbols, names, probe sets, and fold changes are listed. Fold change is defined as NOD/scid expression divided by B6/scid expression. Fold changes <1 are indicated with a negative sign (−) and are reported as 1/fold change. Loci in humans and mice that are associated with T1D or T2D and map close to the identified genes or their human counterparts are identified by one asterisk for each locus and are shown in Table 3.