Inhibition of the expression of penicillin resistance of strain Pen6 by interruption of the murMN operon. Cultures of strains R36A, Pen6, and its mutant derivative carrying an inactivated murMN operon were plated at various cell concentrations on agar containing serial dilutions of penicillin, and the population analysis profiles were determined as described in Experimental Procedures. Strain R36A, ◊; Pen6, ■, and mutant Pen6murMN, X.