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. 2000 Apr 11;97(9):4908–4913. doi: 10.1073/pnas.070050797

Figure 4.

Figure 4

Amino acid sequence of the cytokeratin recognized by scFv-278. The predicted aa sequence of the antigen, here denoted “BFcytokeratin”, is aligned with those of the two most closely related proteins described heretofore, the cytokeratins XenCK55(5/6) and otokeratin. The residues of the inner-ear cytokeratin and identical residues in the other proteins appear in reverse contrast; dashes represent gaps and periods denote stop codons. The predicted α-helical coiled-coil domain of BFcytokeratin extends from residues 131 to 446. The original cytokeratin clone extended only to the codon for residue 66; the remaining 5′ sequence was isolated by using a PCR-based strategy.