Table 1.

DAAOX selectively depletes d-serine in cerebellar slices

Amino acid	Content, nmol/mg protein		Effect of DAAOX, % of control
	Before DAAOX	After DAAOX
l-serine	7.2  ± 0.3	8.1  ± 0.6	112.5
d-serine	1.1  ± 0.20	0.12  ± 0.03	10.9*
Glycine	2.8  ± 0.7	2.7  ± 0.4	96.4
l-Glutamate	25.5  ± 3.0	28.5  ± 4.5	111.8
l-Glutamate	18.7  ± 1.6	19.7  ± 1.8	105.3
l-Aspartate	9.6  ± 1.4	10.9  ± 2.0	113.5
d-Aspartate	0.35  ± 0.07	0.33  ± 0.05	94.3

Separation of free d- and l-amino acids was performed by HPLC as described in Experimental Procedures. Content values are expressed as mean values ± SEM for five independent determinations. 

*P = 0.0095, t test.