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. 1999 Oct 12;96(21):11740–11745. doi: 10.1073/pnas.96.21.11740

Figure 3.

Figure 3

Structures of macrolactones produced by S. lividans strains containing assorted combinations of three plasmids (Fig. 2 and Table 1). The positions in 6dEB (1) that are altered are color coded to correspond to the genetic characteristics of modules 2, 3, 5, and 6 of DEBS that are illustrated in Fig. 1A and Fig. 2, and listed in Table 1. Structures 1–40 and 49–56 are 14-membered lactones, and structures 44–48 are 12-membered lactones. Compounds 49–59 with the C13 propyl group were produced by mutational biosynthesis with the eryAI KS1o null allele.