Growth suppression by BRCA1. Cells were transfected with
equimolar amounts of pcDNA3-BRCA1 or vector alone and selected with
G-418; emerging colonies were stained and counted. The number of
colonies obtained with the vector alone was considered as 100%. pRb
and p53 status of cells is shown. Each experiment was repeated at least
three times, and error bars represent standard deviation. ■,
vector alone transfections; □, BRCA1
transfections. ∗, HBL100 cell line is SV40-positive; ND, not done.