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BRCA1 overexpression in cells with compromised p53 or pRb. (A) Colony formation assay of U2OS control cells or U2OS overexpressing p53Val135 or E7 was performed as in Fig. 1. ■, transfection with vector alone; ░⃞, BRCA1 transfection. (B) Western blot analysis of p53 and p21 proteins induction 18 h after treatment with Adriamycin.
