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A mutant BRCA1 protein bearing a deletion of the Rb binding domain does not suppress cell growth. Colony formation assay was performed in U2OS cells (as in Fig. 1) with wild-type BRCA1 or BRCA1 bearing an in-frame deletion of 90 aa (amino acids 303–394) or a COOH-terminal truncation. Each transfection was done in triplicate in three independent experiments.
