Table 2.

Par-1b null mice (KO) exhibit increased glucose infusion rate and turnover during hyperinsulinemic–euglycemic clamp relative to wild-type mice (WT)

Mice	Basal glucose, mg/dl	Clamp glucose, mg/dl	Glucose infusion rate, mg/kg/min	Basal HGP, mg/kg/min	Clamp HGP, mg/kg/min	Glucose turnover, mg/kg/min	Whole body glycolysis, mg/kg/min	Glycogen synthesis, mg/kg/min
WT	105 ± 5	109 ± 6	45.1 ± 4.5	16.6 ± 2.3	0.6 ± 2.8	45.4 ± 2.9	29.1 ± 3.5	17.3 ± 2.9
n	22	12	9	12	9	12	11	11
KO	94 ± 5	113 ± 5	61.0 ± 4.6	16.1 ± 1.9	−0.1 ± 4.5	58.9 ± 5.6	30.7 ± 4.1	28.2 ± 4.4
n	19	10	7	10	7	10	10	10
P	0.12224	0.6878	0.0284*	0.8769	0.8954	0.0364*	0.7576	0.0515

Mice were fed a standard chow diet (4.5% fat). Twenty-week-old male mice were subjected to clamp as described (33). Values are stated as mean ± SEM. Sample number (n) and P values from a Student's t test are indicated (asterisk indicates significance).