Fig. 1.

Exercise selectively increases dentate gyrus CBV in mice. (a) Exercise had a selective effect on dentate gyrus CBV. Bar graphs show the mean relative CBV (rCBV) values for each hippocampal subregion in the exercise group (filled bars) and the nonexercise group (open bars) over the 6-week study. The dentate gyrus was the only hippocampal subregion that showed a significant exercise effect, with CBV peaking at week 4, whereas the entorhinal cortex showed a nonsignificant increase in CBV. (b) An individual example. (Left) High-resolution MRI slice that visualizes the external morphology and internal architecture of the hippocampal formation. (Center) Parcellation of the hippocampal subregions (green, entorhinal cortex; red, dentate gyrus; dark blue, CA3 subfield; light blue, CA1 subfield). (Right) Hippocampal CBV map (warmer colors reflect higher CBV).