Fig. 2.

Exercise-induced increases in dentate gyrus CBV correlate with neurogenesis. (a) (Left) Exercising mice were found to have more BrdU labeling compared with the no-exercise group. (Right) As shown by confocal microscopy, the majority of the new cells were colabeled with NeuN (red, BrdU labeling; green, NeuN; yellow, BrdU/NeuN double labeling). (b) (Left) A significant linear relationship was found between changes in dentate gyrus CBV and BrdU labeling. (Right) A quadratic relationship better fits the data. The vertical stippled line in each plot splits the x axis into CBV changes that decreased (left of line) versus those that increased (right of line) with exercise.