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. 2007 Mar 20;104(13):5638–5643. doi: 10.1073/pnas.0611721104

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© 2007 by The National Academy of Sciences of the USA

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Fig. 4. — Exercise-induced increases in dentate gyrus CBV correlate with aerobic fitness and cognition. (a) (Left) VO₂max, the gold-standard measure of exercise-induced aerobic fitness, increased after exercise. (Right) Cognitively, exercise has its most reliable effect on first-trial learning of new declarative memories. (b) (Left) Exercise-induced changes in VO₂max correlated with changes in dentate gyrus (DG) CBV but not with other hippocampal subregions, including the entorhinal cortex (EC), confirming the selectivity of the exercise-induced effect. (Center) Exercise-induced changes in VO₂max correlated with postexercise trial 1 learning but not with other cognitive tasks, including delayed recognition. (Right) Postexercise trial 1 learning correlated with exercise-induced changes in dentate gyrus CBV but not with changes in other hippocampal subregions, including the entorhinal cortex.