Fig. 3.

DNA methylation profiles of chromosomes 2, 7, 12, and 17 that carry the HOXA, HOXB, HOXC, and HOXD gene clusters. MIRA-enriched fractions from A549 lung cancer cells and from NHBE cells were mixed and hybridized onto Agilent CpG island arrays. The ratio (fold difference) plotted indicates individual probe signals (blue diamonds) for hypermethylated CpG islands in A549 cells (A549/NHBE signal ratio). The numbers indicate selected areas of densely hypermethylated CpG island clusters for the genes indicated at the bottom.