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. 2007 Mar;14(3):117–125. doi: 10.1101/lm.461407

Figure 6.

Figure 6.

Changes in c-Fos expression in the PFC of mice exposed to novel objects. Mice were killed 2 h after a 10-min exposure to novel objects (Exposure). Control mice were not exposed to novel objects (Control). (A) Diagrammatic representation of the area examined for c-Fos immunostaining. (B) Representative photomicrographs of c-Fos immunostaining. Scale bar, 100 μm. (C) Quantification of the changes in the number of c-Fos-positive cells in the PFC (n = 4). (D) Effects of SCH23390 on c-Fos expression in the PFC of mice exposed to novel objects. Saline or SCH23390 (0.05 mg/kg, i.p.) was administered 30 min before training session (n = 5 for control group, n = 4 for saline-treated exposure group, n = 7 for SCH23390-treated exposure group). Values represent the mean ± SE. ANOVA analysis: F(2,13) = 68.151, P < 0.01 for D. *P < 0.05 and **P < 0.01 compared to control group. ##P < 0.01 compared to saline-treated exposure group.