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. 2007 Mar;14(3):177–184. doi: 10.1101/lm.425907

Figure 2.

Figure 2.

Action of the selective COX-2 inhibitor NS-398 on excitability, paired-pulse facilitation, and LTP. (A) Input/output curves did not show significant changes between control recording and after NS-398 application (10 μM; n = 13). (B) NS-398 (10 μM) caused an impairment of paired-pulse facilitation (n = 13). (C) NS-398 (n = 7) significantly suppressed LA-LTP in wild-type mice in comparison to DMSO-treated controls (n = 7). Representative traces were recorded 5 min prior to tetanus and 60 min after tetanus in the lateral nucleus of the amygdala. Application of high-frequency stimulation (HFS; 2 × 100 Hz, duration 1 sec, interval 30 sec) at time 0. Data points represent averaged amplitudes (mean ± SEM) normalized with respect to baseline values.