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. 2007 Mar;14(3):177–184. doi: 10.1101/lm.425907

Figure 3.

Figure 3.

Interaction between paired-pulse facilitation and LTP. (A) The plot of the ratios of second to first responses at varying interpulse intervals recorded 60 min after induction of LTP (Post) in wild-type mice indicates that responses in the LA were significantly less facilitated throughout interpulse intervals of 10–100 msec than control responses recorded before the application of HFS (Pre) (n = 21, P < 0.04). (B,C) Both in heterozygous (n = 25, P < 0.001) and homozygous (n = 21, P < 0.001) COX-2-deficient mice, a significant decrease in paired-pulse facilitation was obtained after induction of LTP over the range of interpulse intervals from 10 to 200 msec. (D) In slices in which NS-398 blocked the induction of LTP, paired-pulse facilitation recorded 60 min after tetanic stimulation did not differ from that recorded before washing in NS-398.