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. 2007 Mar;14(3):177–184. doi: 10.1101/lm.425907

Figure 4.

Figure 4.

Dose-dependent effects of angiotensin-(1-7) on excitability and plasticity in the LA of slices derived from wild-type mice. (A) Ang-(1-7) (0.01 μM) did not change input/output curves significantly; (B) (blue bars) 0.01 μM Ang-(1-7) enhanced paired-pulse facilitation throughout interpulse intervals of 40–90 msec (n = 17); (C) 0.5 μM Ang-(1-7) (n = 8) did not change the magnitude of LA-LTP in comparison to drug-free controls (see Fig. 1D), whereas 0.01 μM significantly increased LA-LTP (n = 8). (D) A779 (0.01 μM), a specific Ang-(1-7) receptor antagonist, blocked the LTP-enhancing effect of Ang-(1-7) (n = 8). The unspecific inhibitor of the NO system L-NAME (200 μM) also blocked the Ang-(1-7)-mediated effect (n = 10). For comparison, the effect of 0.01 μM Ang-(1-7) on the induction of LTP is also presented. (C,D) Application of high-frequency stimulation (HFS; 2 × 100 Hz, duration 1 sec, interval 30 sec) at time 0. Data points represent averaged amplitudes (mean ± SEM) normalized with respect to baseline values.