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Summary of the role of complement and chronic ethanol-induced liver injury
| Genotype | Complement phenotype | Hepatic triglyceride | Hepatic cytokines | ALT |
|---|---|---|---|---|
| Wild type | C3+/C5+ | ⇈ | ⇈ | ⇈ |
| C3-/- | C3-/C5-/+? | ↔ | ⇈ | ↑ |
| C5-/- | C3+/C5- | ⇈ | ↔ | ↔ |
| CD55/DAF-/- | C3++/C5++ | ↑↑↑ | ⇈ | ↑↑↑ |
