Figure 1.

Ets1 expression in human neuroblastomas. (A) Paraffin-embedded human neuroblastoma sections were stained with an anti-Ets1 antibody visualized by diaminobenzidine staining. Ets1 was strongly expressed in undifferentiated neuroblastoma cells (panels b and d), whereas weakly stained Ets1 was found in well-differentiated neuroblastoma sections (panels a and c). Original magnification: x200 for panels (a) and (b); x400 for panels (c) and (d). (B) Ets1 protein was expressed in 18 of 21 (86%) undifferentiated tumor sections, and in 7 of 16 (44%) differentiated tumor sections.