Figure 2.

Immunohistochemical analysis for the protein expression of DAPK in methylated and unmethylated esophageal tissues representative of non-neoplastic, metaplastic, and neoplastic alterations. Methylation of DAPK promoter resulted in decreased and partial loss of DAPK protein expression (original magnification, x10 and x40). Nontumorous esophageal squamous cell epithelium: unmethylated (A), methylated (B); BE: unmethylated (C), methylated (D); dysplasia of Barrett's mucosa: unmethylated (E), methylated (F); BA: unmethylated (G), methylated (H).