Table 2.
Analysis of Immunohistochemical DAPK Protein Expression and Clinicopathological Features of Advanced BAs.
| IRS of DAPK Protein Expression | P | |||
| 0–3 | 4–8 | 9–12 | ||
| Age in years (median ± 8.89) | 64.3 ± 6.53 | 63.3 ± 10.55 | 62.7 ± 6.65 | .947* |
| Sex | ||||
| Male | 14 | 30 | 13 | .296† |
| Female | 1 | 5 | 0 | |
| Tumor differentiation | ||||
| Mild | 0 | 5 | 2 | .127† |
| Moderate | 2 | 14 | 5 | |
| Poor | 13 | 17 | 8 | |
| Depth of invasion | ||||
| pT1, pT2 | 0 | 20 | 13 | .000† |
| pT3, pT4 | 15 | 16 | 2 | |
| Lymph node metastasis | ||||
| Negative | 10 | 30 | 14 | .157† |
| Positive | 5 | 6 | 1 | |
| Lymph invasion | ||||
| Negative | 4 | 17 | 10 | .090† |
| Positive | 11 | 19 | 35 | |
| Metastasis | ||||
| Negative | 11 | 34 | 14 | .071† |
| Positive | 4 | 2 | 1 | |
| Stage | ||||
| I, II | 3 | 26 | 14 | .001† |
| III, IV | 12 | 10 | 1 | |
Correlation of clinicopathological markers and immunohistochemical protein expression of DAPK in a tissue microarray of 66 advanced BAs.
IRS = immunoreactive score, merged into three groups for statistical analyses (0–3, 4–8, and 9–12 points).
*
One-way analysis ANOVA.
†
Chi-square test.