. 2007 Mar 2;104(11):4279–4284. doi: 10.1073/pnas.0609279104

Table 1.

Phylogenetic distribution of the DIP biosynthesis pathway in bacteria and archaea

Organisms	Four-step DIP biosynthesis pathway				DIP production
Organisms	IPS	IMPCT	PDIPS	IMP	DIP production
T. maritima	TM1419	TM1418a	TM1418b	TM1415	Known
T. neapolitana	020_1986	020_1988	020_1989	020_1993	Known
Aquifex aeolicus	aq_1763	aq_1367^N	aq_1367^C	aq_1983	Known^*
Rubrobacter xylanophilus	Rxyl021258	Rxyl021259^N	Rxyl021259^C	Rxyl021693	Known
Novosphingobium aromaticivorans	Saro3074	Saro3073	Saro3075	Saro2521	Predicted
Uncultured bacterium 17H9	17H9_20	17H9_22^N	17H9_22^C	17H9_21	Predicted
A. pernix	APE1517	APE1514	APE1516	APE1798	Confirmed
Ar. fulgidus	AF1794	AF0263^N	AF0263^C	AF2372	Known
Pyrococcus horikoshii	PH1605	PH1219^N	PH1219^C	PH1897	Predicted
Pyrococcus abyssi	PAB1989	PAB2433^N	PAB2433^C	PAB0189	Predicted
Pyrococcus furiosus	PF1616	PF1058^N	PF1058^C	PF2014	Known
Thermococcus kodakaraensis	TK2278	TK2279^N	TK2279^C	TK0787	Known^*
Uncultured archaeon GZfos13E1	GZ13E1_33	GZ13E1_32^N	GZ13E1_32^C	GZ13E1_31	Predicted

Genes encoding four enzymes of DIP pathway are shown by standard GenBank identificators. N and C superscripts denote N-terminal and C-terminal domains in the fusion IMPCT–PDIPS proteins. Organisms experimentally shown to produce DIP are indicated in the last column (4, 7). DIP production in A. pernix was predicted and confirmed in this study.

*Cases when DIP production was confirmed in subspecies related to but distinct from those with available genomic sequences.