Fig. 4.

Expression of Abcc6 is associated with decreased systemic OPN response. (A) QPCR results showed after HP diet treatment that there is an up-regulation of Spp1 gene in liver, heart, aorta, and muscle tissues in the C3H mice but not in Abcc6 transgenic mice. Relative expression values are compared with transcript levels in Abcc6 transgenics (100). P values are indicated. (B) A plasma OPN surge was observed for C3H mice after the mice were fed an HP diet for 7 days. The surge was completely abolished in Abcc6 transgenic mice. ∗, P < 0.05.