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. 2007 Mar 7;104(11):4682–4687. doi: 10.1073/pnas.0611692104

Fig. 3.

Fig. 3.

Orai1 suppresses the spontaneous activity of TRPC3 channels. (A) Representative single-channel activity records obtained from cell-attached membrane patches of control HEK-293 cells at holding potentials. (Bi) Representative records T3-65 cells overexpressing TRPC3. (Bii) Single-channel I–V relationship for TRPC3 channels of T3-65 cells. γ, single-channel conductance. (C) Representative records from Orai1-expressing T3–65 cells. (D) Summary of channel activity, expressed as average NPo per patch, recorded from HEK 293 cells, YFP-transfected T3–65 cells, and T3-65 cells transfected with plasmids encoding YFP and Orai1 (60 ng). NPo of Orai1-expressing cells is significantly smaller (P < 0.001 based on Wilcoxon–Mann–Whitney rank sum test).