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A plausible model of the molecular makeup of Icrac channels activated by STIM1. STIM1 senses the depletion of Ca2+ from the endoplasmic reticulum stores. Orai, a regulatory β-subunit of the TRPC ion channel α-subunit, is shown as the transducer of the STIM1 signal into activation of TRPC. PM, plasma membrane; ER, endoplasmic reticulum.
