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Cells overexpressing targeted HsMetAP1 resisted compound 1 in cell proliferation assay
| Compound | HeLa proliferation IC50, μM |
||
|---|---|---|---|
| Vector | MetAP1 overexpression | MetAP2 overexpression | |
| Paclitaxel | 0.0023 ± 0.0003 | 0.002 ± 0.0003 | 0.0022 ± 0.0003 |
| 1 | 0.6 ± 0.1 | 2.9 ± 0.4 | 0.7 ± 0.2 |
Each experiment was conducted in triplicate.
