Fig. 5.

Overexpression of miR-195 induces cardiac dysfunction caused by cardiac growth. (A) Echocardiographic analyses indicate miR-195 Tg mice show left ventricle dilation and wall thinning, resulting in a decreased fractional shortening compared with WT littermates. Representative m-mode images are shown. (B) The ratio of heart weight to body weight in response to cardiac-specific overexpression of miR-195. (C) Real-time PCR analysis shows an up-regulation of hypertrophic genes in miR-195 Tg animals compared with WT animals (n = 3; mean ± SEM; ∗P < 0.05).