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. 2006 Nov 17;103(48):18261–18266. doi: 10.1073/pnas.0606108103

Fig. 5.

Fig. 5.

NOTCH and c-MYC constitute a feed-forward regulatory network motif controlling cell growth. (a) Structure of the NOTCH1 feed-forward-loop regulatory motif controlling c-MYC and cell growth genes. (b) NOTCH1 inhibition with GSI in T-ALL cells switches off genes up-regulated by forced expression of c-MYC in T cell lymphoblasts. Graphic representation of the GSEA enrichment score and distribution of c-MYC-regulated genes along the rank of GSI-regulated transcripts. (c) Retroviral expression of c-MYC in DND41 rescues cell growth after GSI treatment. Cell size was estimated by flow cytometry in DND41 cells infected with pBMN c-MYC IRES GFP retrovirus growing in the presence of CompE or vehicle (DMSO) for 4 days.