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Differential endosomal distribution of wt-AQP2, AQP2-K270R, and AQP2-Ub
| Endosome | Distribution of endosomal AQP2, % | |||
|---|---|---|---|---|
| Type I | Type II | Type III | Limiting membrane | |
| wt-AQP2 | 10 | 40 | 50 | 20 |
| AQP2-K270R | 30 | 30 | 40 | 45 |
| AQP2-Ub | 0 | 27 | 73 | 5 |
Quantifications were performed on ultrathin cryosections of MDCK cells labeled for AQP2. For each counting, 30 endosomes were analyzed. Endosomes are divided into three types: I, early endosome; II, late endosome; III, late endosome/lysosome.
