Figure 4.

Unrooted phylogenetic tree of the UmuC/DinB superfamily. The tree was generated from a complete multiple alignment of the UmuC/DinB superfamily of proteins (L.A., unpublished work; available on request). The circles indicate internal nodes with at least 75% bootstrap support. The subfamilies are indicated as follows: UmuC, green; DinB, red; Rad30, blue; and Rev1, pink. The apparent human ortholog of Rev1 was not included, because the sequence is incomplete. Abbreviations are defined in the legend to Fig. 3 and as follows: Dbh Sso, DinB homolog from S. sofataricus; Mpn, Mycoplasma pneumoniae; Mge, Mycoplasma genitalium; Bs, Bacillus subtilis; SPBc2, bacteriophage SPBc2; Mtu, Mycobacterium tuberculosis; and At, Arabidopsis thaliana.