Table 1.
Effects of dietary soy protein in animal models of obesity.
| Model | Diet and Amount | Duration | Effects | References |
|---|---|---|---|---|
| Obese Wistar fatty rats | soybean protein isolate vs casein | 3 wks | Decreased BW, and plasma and liver triacylglycerols, decrease activity of lipogenic enzymes | 36 |
| Male Wistar fatty rats | Soybean protein isolate vs casein | 3 wks | Increased insulin receptor mRNA in liver and adipose tissues, decreased insulin resistance | 37 |
| Dietary obese male Sprague-Dawley rats and Obese yellow KK mice | Soy protein isolate and hydrolysate vs casein protein, 35 % high-protein, 5% low-fat | 2 wks | Decreased body fat and plasma glucose in mice | 38 |
| Genetically obese mice | Soy protein isolate and hydrolysate vs milk whey protein isolate and hydrolysate | 2 wks | Decreased BW and perirenal fat | 39 |
| Obese KK-Ay mice | Soy protein isolate vs casein protein, isocaloric 15g, 100g diet | Decreased BW, bodyfat content, mesenteric, epididymal, and brown fat weight | 40 | |
| Zucker fa/fa rats | Soybean protein diet isolate vs casein | Life-time | Prevented hyperphagia, prolonged survival | 41 |
| Zucker fa/fa rats | Soybean protein diet vs casein | 160 days | Decreased lipogenesis, decreased SERBP-1 and FAS | 60 |