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. 1999 Oct 12;96(21):11928–11933. doi: 10.1073/pnas.96.21.11928

Figure 2.

Figure 2

Liver-function tests and plasma amino acid levels for Fah−/− mice with varying Hgd genotypes. (A) ALT (alanine aminotransferase) levels. (B) BC (conjugated bilirubin) levels. (C) Plasma tyrosine levels. Double-mutant mice (−/−) are shown with both short-term (4-week) and long-term (LT) (12- to 14-month) periods off of NTBC. +/−, Hgd heterozygote; +/+, Hgd wild type; aku, alkaptonuria controls (Fah wild type). Numbers of mice from each genotype used throughout this study are given in parentheses.