(A–D) C57BL/6 female (A and B) and male (C and D) +/+, l/+, and l/l animals were provided NC (A and C) or HF (B and D) diets from the age of 5 weeks and weighed weekly until 12 weeks of age. All values represent mean ± SEM. ANOVA and repeated measures ANOVA, P = NS, except for #P < 0.02 for l/l versus other groups where indicated. (E) Weight gained per female mouse from 5–12 weeks of age on each diet. (F) Food intake for first week of divergent diet for female mice of the indicated genotype. *P < 0.05, **P < 0.01 versus +/+ animals, by ANOVA.