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. 2007 Apr 5;117(5):1324–1334. doi: 10.1172/JCI31240

Figure 3. The proximal promoter region mediates inducible expression of the STARS gene.

Figure 3

(A) LacZ staining and activity (n = 4) of adult Tg mouse hearts carrying construct 1 in wild-type or Cn-Tg mice. Original magnification, ×2. (B) Luciferase activity of cardiomyocytes transfected with –1581STARS-Luc or control pGL3 treated with 100 nM ET, 100 μM PE, or 1 nM leukemia inhibitory factor (LIF) for 24 hours. (C) Luciferase activity of cardiomyocytes transfected with –1581- or –164STARS-luc with or without mutations in the M1 or M2 regions and treated with 100 μM PE for 24 hours. *P < 0.05 versus the reporter without mutation.