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. 2007 Apr 2;117(4):971–977. doi: 10.1172/JCI29988

Figure 4. Recovery of β cell mass after Ppx and biological efficacy of Ex-4 treatment.

Figure 4

(A) Glucose tolerance tests were performed i.p. 2 weeks after Ppx or sham surgery in mice treated with vehicle or Ex-4 (n = 4–5 per group). Black line denotes sham surgery plus treatment with vehicle, blue dashed line denotes Ppx plus treatment with vehicle, gray line denotes sham surgery plus treatment with Ex-4, and dashed black line denotes Ppx plus treatment with Ex-4. P < 0.05, Ppx plus vehicle versus all other groups; ANOVA. (B) Mass of β cells (in mg) was determined by point counting morphometry 4–5 weeks after surgery. (C) Weight (in g) of the pancreatic remnant at 4–5 weeks after surgery.