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. 2007 Apr 2;117(4):1068–1077. doi: 10.1172/JCI30117

Figure 5. Inhibition of Hif prolyl hydroxylation results in an Hif-2–dependent induction of hepatic Epo.

Figure 5

Relative Epo mRNA levels in the liver of albumin-Cre mutant mice treated with either with normal saline or 10 mg of DMOG as determined by real-time PCR. Bars represent the mean Epo mRNA transcript level of 3 mice for the WT and albumin–Hif-1α mutants (Hif-1α–/–) and 5 mice for the albumin-Hif-2α (Hif-2α–/–) mutants. Error bars represent SEM. *P < 0.05 compared with albumin–Hif-2α mutant mice as determined by the Wilcoxon rank sum test.