Figure 6. Site-specific deletion of hAGT protein in the SFO.

Representative coronal sections through the SFO from mice injected with either AdEGFP alone or both AdEGFP and AdCre directly into the SFO. AGT was localized by immunofluorescence (red) and EGFP by its intrinsic fluorescence (green). A–C show colocalization of AdEGFP and AGT but no deletion or diminution of AGT staining. The arrows in C indicate EGFP-positive, hAGT-negative cells adjacent to the SFO. D–F show loss of AGT in regions where the virus mixture (AdEGFP and AdCre) is located. The arrow in F represents a cell in which hAGT was not ablated, which may represent a cell infected with AdEGFP but not AdCre.