Table 1.
Effect of 14-3-3 binding on the activity of mammalian protein kinases
| Kinase | Binding site | Upstream kinase | Activitya | Reference |
|---|---|---|---|---|
| PI3K | n.d. | n.d. | − | Bonnefoy-Berard et al. (1995) |
| PKCμ | RRLpSNV (Ser-205) | Autob | − | Hausser et al. (1999) |
| RTSpSAE (Ser-219) | ||||
| Raf-1 | RSApSEP (Ser-621) | n.d. | + | Yip-Schneider et al. (2000) |
| RSTpSTP (Ser-259) | AKT, PKA | − | Light et al. (2002) | |
| TESK1 | RCRpSLP (Ser-437) | n.d. | − | Toshima et al. (2001) |
| Wee1 | RSVpSLT (Ser-642) | Chk1 | + | Rothblum-Oviatt et al. (2001) |
| PDK1 | RANpSFV (Ser-241, catc) | Auto | − | Sato et al. (2002) |
| RSK1 | TRLpSKE (Ser-154, cat) | n.d. | − | Cavet et al. (2003) |
| BMK1 | LLKpSLR (Ser-486) | n.d. | − | Zheng et al. (2004) |
| ASK1 | RSIpSLP (Ser-967, cat) | n.d. | − | Goldman et al. (2004) |
| CaMKK1 | RKFpSLQ (Ser-74) | PKA | − | Davare et al. (2004) |
| GSK-3β | RTTpSFA (Ser-9) | AKT | + | Yuan et al. (2004) |
| SIK | PLSpTWC (Thr-182, cat) | LKB | + | Al-Hakim et al. (2005) |
| MEKK3 | GIRpSVT (Ser-526, cat) | Auto | + | Fritz et al. (2006) |
| PKB/AKT | n.d. | n.d. | − | Yang et al. (2006) |
| DYRK1A | RARpSDP (Ser-520) | Auto | + | This study |
n.d., not described.
a +, stimulation of kinase activity; −, inhibition of kinase activity.
b Auto, autophosphorylation.
c cat, phosphorylated residue is located within the catalytic domain.