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. 2007 Apr;18(4):1293–1301. doi: 10.1091/mbc.E06-09-0841

Figure 2.

Figure 2.

Comparison between duplicated subunits in trypanosomatids. For all panels, conserved structure is in blue, and residues that are predicted to cause alterations to the solved structure or residues that are not present in the solved structure are in green. (A) Cartoon depicting domains and insertions in trypanosomatid RPB5 sequences. (B) Comparison between insertion size and proportion of charged residues for the two largest insertions in the three trypanosomatids. (C) Cartoon depicting domains and insertions in trypanosomatid RPB6 sequences. (D) Comparison between the known S. cerevisiae RPB5 structure and those predicted for T. brucei RPB5 and RPB5z. (E) Comparison between the known S. cerevisiae RPB6 structure and those predicted for T. brucei RPB6 and RPB6z. The structure of the RPB6 charged N-terminal domain is not known and hence is not included. (F) Predicted RPB5z and RPB6z subunits placed in context of an RNA polymerase complex (Pol II), black arrow indicates direction and point of entrance for DNA entering the complex.