Figure 1.

Nucleotide sequence alignment of anchor-determining domains of CEA family members of human and other species compared with human CEA. Identical nucleotides are indicated as dots. Dashes show naturally occurring deletions. Stop codons are underlined and marked by word “STOP.” The conserved Thr codon in GPI-linked members, shown to be important in GPI processing, is underlined and marked by a bold letter T. Positions of two sets of S and AS PCR primers are shown by horizontal arrows. Numbers of sequenced independent clones of PCR products for each species are indicated in brackets. Sequences of three cloned RT-PCR–amplified bands of CMO monkey cDNA (see Materials and Methods) are shown as RT 1–3.