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. Author manuscript; available in PMC: 2007 Mar 29.
Published in final edited form as: Mol Microbiol. 2005 May;56(4):1017–1034. doi: 10.1111/j.1365-2958.2005.04566.x

Table 7.

Correlation between high bias of the cognate amino acid in the biosynthetic enzymes and high relative concentration of the cognate amino acid in the environment.

Rank of amino acid concentrationa
 Rank of minimum cognate biasb
 Rank of minimum cognate biasc
Amino Acid Soil Colon B. subtilis E. coli B. subtilis S. typhimurium
Ala 2 1 2 1 2 1
Arg 1 3 1 2 1 2
Asp 2 1 1 2 1 2
Glu 1 3 1 2 1 2
Gly 3 1 1 2 2 1
Lys 1 3 1 2 1 2
Ser 3 1 2 1 2 1
Thr 2 1 2 1 2 1
Trp 1 3 1 2 1 2
Tyr 1 3 1 2 1 2
Rank correlation (n = 20)d r = 0.61 (P < 0.004) Rank correlation (n = 20)e. r = 0.83 (P < 0.00025)
a

If the concentration of amino acid in the environment is low, then the rank is 1; if it is intermediate, then the rank is 2; if it is high, then the rank is 3.

b

If cognate bias is lower in B. subtilis, then the rank is 1 for B. subtilis and 2 for E coli; if cognate bias is higher in B. subtilis, then the rank is 2 for B. subtilis and 1 for E. coli.

c

If cognate bias is lower in B. subtilis, then the rank is 1 for B. subtilis and 2 for S. typhimurium; if cognate bias is higher in B. subtilis, then the rank is 2 for B. subtilis and 1 for S. typhimurium.

d

Rank correlation calculated using the pair of values (rank of amino acid concentration, rank of minimum cognate bias) for B. subtilis and E. coli.

e.

Rank correlation calculated using the pair of values (rank of amino acid concentration, rank of minimum cognate bias) for B. subtilis and S. typhimurium.