Table 2.

Parameter Changes Required to Double the Output Firing Rate and Their Effects on Gain and Fano Factor.

	Parameter	% Change in Parameter Needed	Fano Factor at 40 Spikes/S After Change	Multiplicative Gain (Slope at 40 Spikes/S)	Consistent with Data?
1	Reset potential	Not possible	NA	NA	No
2	Synchrony of E inputs	+50%	3.85	1.8X	No
3	Synchrony between all input pairs	Not possible	NA	NA	No
4	Membrane time constant	+300%	1.5	1X	No
5	Adaptation conductance	−100%	2.0	2X	Yes
6	Threshold	−1.8%	2.0	2X	Yes

Note: Missing values indicate that it was not possible to double the firing rate using that parameter.