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Ectopic granule cells in the hilus are active during a spontaneous seizure. Immunoreactivity for c-fos and calbindin in a pilocarpine-treated animal that had spontaneous seizures and was sacrificed 3 hours after a spontaneous seizure was observed. A-B) There are two double-labeled neurons in the hilus (arrow), enlarged in B. Calibration = 100 μm (A); 25 μm (B). C) Double-labeled hilar neurons in another animal are shown. Calibration (in A) = 50 μm. Used with permission, ref. 87.
