Conservation of CpG MTase-like proteins in eukaryotes. The general structural organization of different eukaryotic CpG MTase-like proteins are shown with their methylation activities indicated. Those of the bacterial C-methylating enzymes are included for comparison. Of the 10 conserved sequence motifs in the catalytic domains, only I and IV, which are relevant to the present study, are indicated. The boundaries of DmMTR1 and DmMT2 are unknown at the present time, and are represented with the dashed lines. For positions of the conserved motifs in DmMT2, see Fig. 7.