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. Author manuscript; available in PMC: 2008 Feb 1.
Published in final edited form as: Exp Neurol. 2006 Oct 17;203(2):512–520. doi: 10.1016/j.expneurol.2006.09.004

Figure 5. Neuroprotection with glutathione loading against mitochondrial inhibiton in vitro.

Figure 5

Mesencephalic cultures were preloaded for 24hr with 1–5 mM glutathione monoethyl ester (GEE) prior to an additional 24 hr incubation with (A) the complex II inhibitor malonate (50 mM) or (B) the complex I inhibitor MPP+ (0.5μM) . Cells recovered for 3d before assessing toxicity by measurement of the high affinity transport of dopamine. Toxicity was only observed in the mesencephalic dopamine population. The n is from 3–4 experiments for (A) and 2 experiments for (B) run in duplicate per condition. aDifferent from control; bdifferent from mitochondrial inhibitor alone.