Skip to main content
. Author manuscript; available in PMC: 2008 Feb 1.
Published in final edited form as: Exp Neurol. 2006 Oct 17;203(2):512–520. doi: 10.1016/j.expneurol.2006.09.004

Figure 8. Chronic MPP+ produces selective loss of striatal dopamine that is partially protected with co-infusion of GEE Sprague.

Figure 8

Dawley rats were administered either saline-I (0.108 mg/kg/d), glutathione monoethyl ester (GEE, 10 mg/kg/d), MPP+-I (0.142 mg/kg/d, free base), or GEE plus MPP+-I for 28d into the left cerebral ventricle via an osmotic minipump. (A) Selectivity of damage was assessed by HPLC measurement of left and right striatal levels of dopamine (DA), 5-HT, glutamate (Glu) and GABA 28d following MPP+-I infusion. Only DA levels were found to be reduced. The n is from 9 animals. *Different from non-infused side and saline treated control. (B) Striatal DA on the contralateral (right) sides showed no differences with any of the treatments. MPP+-I infusion reduced DA on the ipsilateral (left) side. GEE co-infusion with MPP+ provided partial protection. The n for each group is given in parenthesis. aDifferent from saline control; bdifferent from MPP+ alone. (C) Striatal glutathione (GSH) levels were elevated following GEE infusion, but were significantly lower with MPP+ or MPP+ plus GEE. aDifferent from saline control; cdifferent from GEE alone.