Table 4.
Odds Ratios and 95% Confidence Limitsa for Breast Cancer by Tertiles of Lipid-Adjusted Organochlorines Stratified by Case patient Characteristic
| OR (95% CI) | p-value (interaction)b | ||||
|---|---|---|---|---|---|
| Tumor or Tumor Receptor Protein Status | |||||
| ER positive | #Cases/#Controls | ER negative | #Cases/#Controls | ||
| PCBc | 183/326 | 154/326 | 0.86 | ||
| BDLd | 1.0 (ref) | 1.0 (ref) | |||
| 0.1–0.47 | 0.96 (0.62, 1.51) | 0.88 (0.54, 1.41) | |||
| > 0.47 | 0.92 (0.58, 1.47) | 0.88 (0.54, 1.44) | |||
| DDEc | 184/327 | 154/327 | 0.04 | ||
| ≤ 0.44 | 1.0 (ref) | 1.0 (ref) | |||
| 0.45 – 1.15 | 1.21 (0.70, 2.10) | 0.92 (0.54, 1.57) | |||
| > 1.15 | 1.43 (0.54, 2.50) | 0.80 (0.45, 1.40) | |||
| PR positive | PR negative | ||||
| PCBc | 162/326 | 170/326 | 0.60 | ||
| BDLd | 1.0 (ref) | 1.0 (ref) | |||
| 0.1–0.47 | 0.91 (0.57, 1.45) | 0.88 (0.55, 1.40) | |||
| > 0.47 | 0.79 (0.48, 1.28) | 0.98 (0.61, 1.57) | |||
| DDEc | 163/327 | 170/327 | 0.21 | ||
| ≤ 0.44 | 1.0 (ref) | 1.0 (ref) | |||
| 0.45 – 1.15 | 1.01 (0.58, 1.75) | 1.05 (0.62, 1.79) | |||
| > 1.15 | 1.20 (0.68, 2.12) | 0.96 (0.55, 1.66) | |||
| p53 positive | p53 negative | ||||
| PCBc | 98/326 | 152/326 | 0.32 | ||
| BDLd | 1.0 (ref) | 1.0 (ref) | |||
| 0.1–0.47 | 0.72 (0.41, 1.27) | 0.92 (0.57, 1.48) | |||
| > 0.47 | 0.72 (0.40, 1.27) | 0.97 (0.59, 1.59) | |||
| DDEc | 98/327 | 153/327 | 0.63 | ||
| ≤ 0.44 | 1.0 (ref) | 1.0 (ref) | |||
| 0.45 – 1.15 | 0.93 (0.49, 1.78) | 1.16 (0.66, 2.03) | |||
| > 1.15 | 0.95 (0.49, 1.85) | 1.18 (0.66, 2.12) | |||
| Her2Neu | Her2Neu | ||||
| low | high/moderate | ||||
| PCBc | 194/326 | 56/326 | 0.96 | ||
| BDLd | 1.0 (ref) | 1.0 (ref) | |||
| 0.1–0.47 | 0.87 (0.57, 1.37) | 0.65 (0.31, 1.36) | |||
| > 0.47 | 0.85 (0.53, 1.34) | 0.88 (0.44, 1.78) | |||
| DDEc | 195/327 | 56/327 | 0.15 | ||
| ≤ 0.44 | 1.0 (ref) | 1.0 (ref) | |||
| 0.45 – 1.15 | 1.04 (0.63, 1.72) | 1.23 (0.48, 3.15) | |||
| > 1.15 | 0.96 (0.57, 1.63) | 1.73 (0.68, 4.41) | |||
| Chemotherapy History | |||||
| History of chemotherapy | No history of chemotherapy | ||||
| PCBc | 157/326 | 94/326 | 0.08 | ||
| BDLd | 1.0 (ref) | 1.0 (ref) | |||
| 0.1–0.47 | 1.24 (0.78, 1.98) | 1.06 (0.57, 1.98) | |||
| > 0.47 | 1.06 (0.64, 1.74) | 1.89 (1.06, 3.37) | |||
| DDEc | 157/327 | 95/327 | 0.40 | ||
| ≤ 0.44 | 1.0 (ref) | 1.0 (ref) | |||
| 0.45 – 1.15 | 1.32 (0.76, 2.29) | 0.99 (0.48, 2.08) | |||
| > 1.15 | 1.02 (0.57, 1.84) | 1.24 (0.60, 2.58) | |||
a
Adjustment made for age (35–44 years, 45–54 years and 55–64 years); BMI (<= 24.90 kg/m2, 24.91 – 28.94 kg/m2, 28.95 – 33.65 kg/m2, > 33.65 kg/m2); breastfeeding (continuous variable)
b
From case-case analysis
c
Lipid adjustment done as described by Phillips et al.,1989.
d
BDL: Below Detectable Level for the assay