Table 2.

Whole animal LDL clearance rates in control mice and animals lacking functional NPC1 and/or LDLR activity

LDL transport parameter	NPC+/+/LDLR+/+	NPC−/−/LDLR+/+	NPC+/+/LDLR−/−	NPC−/−/LDLR−/−
Clearance in whole animal, ml/day per kg	555  ±  34	523  ±  59	63  ±  12*	59  ±  11*
Clearance in liver, ml/day per kg	452  ±  32	418  ±  46	25  ±  4*	22  ±  8*
Clearance in extrahepatic tissues, ml/day per kg	103  ±  7	105  ±  8	38  ±  7*	37  ±  9*

Mice of four different genotypes were used in these studies, and all were 7 weeks of age. There were 6–11 mice in each group. An asterisk identifies those values that were significantly different from the corresponding values in the control NPC^+/+/LDLR^+/+ animals. There were no significant differences between values in the NPC^+/+/LDLR^+/+ and NPC^−/−/LDLR^+/+ animals or between the NPC^+/+/LDLR^−/− and NPC^−/−/LDLR^−/− groups.